Turns out that there was a real flaw to our logic.
As we later learned from my pulmonologist, the genetic structure of A1AT was not the simple dominant-recessive relationship that we all recall. It is instead, what is referred to as a Co-Dominant gene.
What does that mean? Well, let's take the example of brown eyes or blue eyes. If the genetics were a simple dominant-recessive relationship, and A is brown eyes (dominant) and B is blue eyes (recessive), then two parents, one with AA, and one with BB, will each contribute one allele, leaving their offspring to be AB. Since the A is the dominant allele, the offsprings eyes will be brown. They will be a carrier of the B allele, meaning that the offspring's children, or further down the family tree, still have a chance to inherit the two recessive alleles necessary to have blue eyes (BB).
On the other hand, A1AT is Co-dominant. That means that BOTH alleles contribute to the makeup of the offspring. It isn't necessarily a 50-50 split (sometimes 60-40, sometimes 40-60, etc...) but a combination of the two regardless. Hence, using our example, the AB offspring would have some combination of the blue and brown color in their eyes.
Wednesday, November 25, 2009
In the words of Lee Corso... Not so fast, my friend!
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